1359. Clinical Experience and Challenges Utilizing Clofazimine in the Treatment of Nontuberculous Mycobacterial Pulmonary Infections
نویسندگان
چکیده
منابع مشابه
MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections.
Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1+/- heterozygous mice display an intermediate killing ability compared with Mpeg1 WT and Mpeg1-/- mice. Despi...
متن کاملDiagnosis of Nontuberculous Mycobacterial Infections
Background The nontuberculousmycobacteria (NTM) are a grouping of all Mycobacterium species other than the obligate pathogens M. tuberculosis complex and M. leprae. They are typically environmental organisms residing in soil and natural as well as treated water.1 Although generally of low pathogenicity to humans, NTM can cause a wide array of clinical diseases; pulmonary disease is most frequen...
متن کاملDiagnosis of nontuberculous mycobacterial infections.
The nontuberculous mycobacteria (NTM) are typically environmental organisms residing in soil and water. Although generally of low pathogenicity to humans, NTM can cause a wide array of clinical diseases; pulmonary disease is most frequent, followed by lymphadenitis in children, skin disease by M. marinum (particularly in fish tank fanciers), and other extrapulmonary or disseminated infections i...
متن کاملNontuberculous Mycobacterial Pulmonary Disease
Tuberculosis (TB) is an infectious and transmissible disease caused by Mycobacterium tuberculosis and closely related mycobacterial species (M. bovis, M. africanum, and M. microti). These species, obligate pathogens, compose what is known as the M. tuberculosis complex. Nontuberculous mycobacterial (NTM) species are mycobacterial species other than those belonging to the Mycobacterium tuberculo...
متن کاملHost response to nontuberculous mycobacterial infections of current clinical importance.
The nontuberculous mycobacteria are a large group of acid-fast bacteria that are very widely distributed in the environment. While Mycobacterium avium was once regarded as innocuous, its high frequency as a cause of disseminated disease in HIV-positive individuals illustrated its potential as a pathogen. Much more recently, there is growing evidence that the incidence of M. avium and related no...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2019
ISSN: 2328-8957
DOI: 10.1093/ofid/ofz360.1223